PRISMA strongly recommends the use the safe mode to manage your permission groups. The safe mode is set by default and grants you access to all Standard Groups relevant to your company type. These groups include all the necessary permissions so that regular users and administrators can make full use of the platform without issues.
If you turn off the safe mode, however, you activate the advanced mode which allows you create custom groups in which you can mix and match different permissions according to your company needs. The advanced is at this point a beta features. PRISMA cannot therefore guarantee that the combinations of permissions in custom groups will not cause mutual incompatibilities which might obstruct your users' access to certain platform feature.